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Weight Gain and the Gut Brain Axis

The gut-brain axis is a highly sophisticated communication system between the gut and the brain, consisting of a complex network of neurons, hormones, and immune cells that work together to regulate digestion, metabolism, appetite, and satiety.


The gut-brain axis is responsible for sending signals from the gut to the brain and vice versa.


For example, when you eat a meal, the gut releases hormones that signal to the brain that you are full, which can reduce your appetite and help you stop eating. Conversely, when you are under stress, the brain can send signals to the gut, triggering changes in digestive function, such as decreased motility and increased inflammation.

One way that the gut-brain axis can affect weight loss is through the regulation of hunger and satiety. When the gut releases hormones that signal satiety, it can help reduce appetite and prevent overeating, which can lead to weight loss.


Ghrelin and leptin are two essential hormones released by the gut that signal hunger and fullness, respectively. Ghrelin increases appetite and stimulates the release of growth hormone, while leptin suppresses appetite and regulates energy balance.


However, when the gut-brain axis is disrupted, it can lead to imbalances in these hormones, which can result in increased hunger and decreased satiety, making it harder to lose weight.


Another way that the gut-brain axis can impact weight loss is through the regulation of metabolism. Studies have shown that the gut microbiome, which is the collection of microorganisms that live in the GI tract, can influence metabolism and energy expenditure. Bifidobacterium and Lactobacillus are two strains of beneficial bacteria that have been linked to improved metabolism and reduced inflammation.


On the other hand, imbalances in the gut microbiome, such as an overgrowth of harmful bacteria, have been associated with weight gain and metabolic disorders.



There are several things that you can do to support a healthy gut-brain axis and improve your weight loss outcomes.


Eat a healthy diet: Consuming a diet that is rich in fruits, vegetables, whole grains, and lean protein can help support a healthy gut microbiome, which can improve metabolism and energy expenditure.


Manage stress: Stress can disrupt the gut-brain axis, leading to imbalances in appetite and metabolism. Incorporating stress-reducing activities into your daily routine, such as meditation or yoga, can help support a healthy gut-brain axis.


Exercise regularly: Regular exercise has been shown to improve gut microbiome diversity, which can support a healthy gut-brain axis and improve weight loss outcomes.


Get enough sleep: Sleep is essential for the proper functioning of the gut-brain axis. Aim to get 7-9 hours of sleep each night to support a healthy gut-brain axis and improve weight loss outcomes.


Consider probiotics: Probiotics are live microorganisms that can help improve gut microbiome diversity and support a healthy gut-brain axis.

The gut-brain axis is a complex communication system that plays a critical role in regulating weight loss outcomes. By making lifestyle changes that support a healthy gut-brain axis, you can improve your metabolism, promote weight loss, and achieve your weight loss goals.


When the gut microbiome is healthy and diverse, it can help regulate metabolism, leading to improved weight loss outcomes. However, when the gut microbiome is disrupted, it can lead to imbalances in metabolism, which can contribute to weight gain.

Medical Disclaimer:
While I am a nurse practitioner, I am not YOUR health care professional. The information provided on
this website is not intended to be a substitute for professional medical advice, diagnosis, or treatment.
Always seek the advice of your physician or other qualified healthcare provider with any questions you
may have regarding a medical condition.

The views expressed on this website are my own and do not reflect the views of my employer.

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